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KMID : 0377220010260010040
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Medical Journal of Chosun Univercity
2001 Volume.26 No. 1 p.40 ~ p.43
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Expression Pattern of p53 Protein in Astrocytoma according to the Histologic Grade
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Kee Keun-Hong
Yang Jeong-Won
Lee Seung-Hak
Lee Min-Oh
Sung Jung-Hee
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Abstract
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Background and Objectives: Mutation or inactivation of the p53 is important mechanism in a wide variety of human tumors. The purpose of this study is to investigate the relationship between expression amount of p53 protein and the grade of astrocytic gliomas.
Materials and Methods: This study analyzes 40 paraffin-embedded astrocytic glioma, including 10 cases of low grade, 20 cases of high grade, and 10 cases of maligant glioma (glioblastoma multiforme) were used to analyze the status of abnormal accumulation of wild type of p53 protein. The evaluation of the immunostaining result was based on the percentage of positive neoplastic cells.
Results: Average positive cell rate of p53 protein were 4.2%, 35.4% and 16.2% in low grade astrocytoma, high grade astrocytoma and glioblastoma multiforme, respectively.
Conclusion: p53 gene mutations were correlated with histologic grade of glial tumors. High grade and glioblastoma multiforme showed higher positive cell rate than low grade astrocytoma. These results suggest that the high positive rates of p53 protein is related to the poor prognosis.
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KEYWORD
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Astrocytoma, Grade, p53 protein
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